|Session Title: Evolutionary and Population Genetics Session Type: Poster|
|Session Location: Exhibit Hall, Level 2, Convention Center Session Time: Wed 10:00AM-7:00PM|
|Program Number: 439W Presentation Time: Wed, Oct 12, 2011, 2:00PM-3:00PM|
|Keywords: Evolutionary and Population Genetics, KW008 - BIOINFORMATICS, KW141 - POPULATION STRUCTURE, KW078 - GENOME SCAN, KW094 - LINKAGE DISEQUILIBRIUM, KW108 - METHODOLOGY|
Estimating a date of mixture of ancestral South Asian populations. P. Moorjani1,2, N. Patterson2, P. Govindaraj3, L. Singh3,4,5, K. Thangaraj3,5, D. Reich1,2,5 1) Dept Gen, Harvard Medical School, Boston, MA; 2) Broad Institute, Cambridge, MA; 3) Centre for Cellular and Molecular Biology, Hyderabad, India; 4) Genome Foundation, Hyderabad, India; 5) These authors co-directed the project.|
Linguistic and genetic studies have shown that most Indian groups have ancestry from two genetically divergent populations, Ancestral North Indians (ANI) and Ancestral South Indians (ASI). However, the date of mixture still remains unknown. We analyze genome-wide data from about 60 South Asian groups using a newly developed method that utilizes information related to admixture linkage disequilibrium to estimate mixture dates. Our analyses suggest that major ANI-ASI mixture occurred in the ancestors of both northern and southern Indians 1,200-3,500 years ago, overlapping the time when Indo-European languages first began to be spoken in the subcontinent. These results suggest that this formative period of Indian history was accompanied by mixtures between two highly diverged populations, although our results do not rule other, older ANI-ASI admixture events. A cultural shift subsequently led to widespread endogamy, which decreased the rate of additional population mixtures.
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