Abstract/Session Information for Program Number 466W
Session Information
Session Title: Evolutionary and Population Genetics   Session Type: Poster
Session Location: Exhibit Hall, Level 2, Convention Center   Session Time: Wed 10:00AM-7:00PM
Abstract Information
Program Number: 466W  Presentation Time: Wed, Oct 12, 2011, 3:00PM-4:00PM
Keywords: Ethical, Legal, Social and Policy Issues in Genetics, KW054 - ETHICAL, LEGAL AND SOCIAL ISSUES, KW141 - POPULATION STRUCTURE, KW057 - EVOLUTIONARY GENETICS, KW056 - EVOLUTION, KW072 - GENETIC DIVERSITY
Abstract Content
Exceptions to the "One Drop Rule"? DNA evidence of African ancestry in European Americans. J. L. Mountain1, J. M. Macpherson1, C. B. Do1, B. T. Naughton1, R. A. Kittles2, N. Eriksson1 1) 23andMe, Inc, Mountain View, CA; 2) Institute of Human Genetics, University of Illinois at Chicago, Chicago, IL.

   Genetic studies have revealed that most African Americans trace the majority (75-80%, on average) of their ancestry to western Africa. Most of the remaining ancestry traces to Europe, and paternal lines trace to Europe more often than maternal lines. This genetic pattern is consistent with the "One Drop Rule, a social history wherein children born with at least one ancestor of African descent were considered Black in the United States. The question of how many European Americans have DNA evidence of African ancestry has been studied far less. We examined genetic ancestry for over 77,000 customers of 23andMe who had consented to participate in research. Most live in the United States. A subset of about 60,000 shows genetic evidence of fewer than one in 16 great-great-grandparents tracing ancestry to a continental region other than Europe. They are likely to consider themselves to be entirely of European descent. We conducted two analyses to understand what fraction of this group has genetic evidence of some ancestry tracing recently to Africa. We first identified individuals whose autosomal DNA indicates that they are predominantly of European ancestry, but who carry either a mitochondrial (mt) DNA or Y chromosome haplogroup that is highly likely to have originated in sub-Saharan Africa. Of the 60,000 individuals with 95% or greater European ancestry, close to 1% carry an mtDNA haplogroup indicating African ancestry. Of approximately 33,000 males, about one in 300 trace their paternal line to Africa. We then identified the subset of these European Americans who have estimates of between 0.5% and 5.0% of ancestry tracing to Africa. This subset constitutes about 2% of this set of individuals likely to be aware only of their European ancestry. The majority (75%) of that group has a very small estimated fraction of African ancestry (about 0.5%), likely to reflect African ancestry over seven generations (about 200 years) ago. We estimate that, overall, at least 2-3% of individuals with predominantly European ancestry have genetic patterns suggesting relatively deep ancestry tracing to Africa. This fraction is far lower than the genetic estimates of European ancestry of African Americans, consistent with the social history of the United States, but reveals that a small percentage of mixed race individuals were integrating into the European American community (passing for White) over 200 years ago, during the era of slavery in the United States.

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